Human Growth Hormone® Information
Edward Lichten, M.D.,PC
There is an old adage that states that......
If this is true, why should it follow that experience and financial security are 'wasted on the old’ because they have lost the energy and enthusiasm to enjoy the 'golden years?'
This does not have to be the case. For we have come to learn that old age is simply a state of hormonal deficiency, a state of lacking the previously bountiful hormones of youth. Then it follows that, these symptoms of ‘old age’ are actually symptoms that can be reversed.
Leading the list of the age-depleted hormones that can be replaced and provide for longer, healthier, and more productive lives is the human growth hormone (HGH).
One of the 6 key hormones of the life-pyramid, Growth hormone is obviously
natural and quite plentiful in the human body during youth. In fact, it is a substance that actually retains the properties of youthful
repair, but lessened with age.
Growth hormone is essential to growth. It is a supplement given to children who suffer with abnormally slow bone growth to enable them to grow taller. But HGH levels fall steadily in everyone once they reach adulthood. Since we now realize that HGH is indispensable throughout life, it must be considered a vital hormone for maintenance of the adult body. Studies of its amazing effects in the elderly population supports its primary role in improved longevity and the betterment of the quality of one’s life.
Produced in the anterior section of the pituitary gland
deep in the brain, HGH is a microscopic protein substance. Chemically, it is
somewhat similar to insulin although it is secreted in short pulses during the
first hours of sleep and after exercise; it only remains in the circulation
for a few minutes. As such, it is extremely difficult to measure HGH in blood
serum. However, the body binds most of the growth hormone in the liver and
converts some of the hormone into Insulin-like Growth Factor- I (IGF-I). Since
IGF-1 remains in the blood stream for 24-36 hours, a blood sample identifying
IGF-1 will be a more dependable indicator of competent HGH production. Normal
IGF-1 blood levels in adults range from 200 to 450 ng/ml (nanograms per milliliter). Yet, one-third of individuals over 50 years of age show abnormal levels less than 200 ng/ml. During the growth spurt of youth, HGH levels are maximum and the
IGF-1 will be measured well over 600- 800 ng/ml. Yet for normal men and women under 40, less than 5%
should have levels below 250 ng/ml! After 40 many men and women have the same amount of HGH as an octogenerian! And that may be
one of the keys to aging as we now know it!
When one’s IGF-1 level falls below the adult normal range, his/her muscle and bone strength and energy levels most likely will decrease. Tissue repair, cell
repair, healing capacity, upkeep of vital organs, brain and memory function, enzyme production, and revitalization of hair, nails and skin will also diminish. While aging and decreasing growth hormone levels go 'hand-in-hand' those who lose their pituitary production of HGH due to surgery, infection or accident, instantly suffer many profound, ill effects.
It is important to reiterate that
In those who have no pituitary function, there is a shift in body composition whereby body fat increases by 7-25% while lean body mass decreases similarly. Muscle strength and muscle mass are noticeably reduced. Bone density studies indicate long bone density and spinal bone density decrease as significantly as if the individual had aged 15 years. Pronounced weight gain of 30-50 pounds occur when HGH wanes. Furthermore, there are negative effects on cholesterol; triglyceride levels increase while high density cholesterol (HDL), a ‘good cholesterol’, decreases. Increased risk of cardiovascular disease may be related to vascular wall thickening and changes associated with decreased cardiac output. Such insufficiencies may contribute to these people reporting a rapid decline in exercise capacity and early deaths from heart disease. They also report an impaired sense of well-being and symptoms of fatigue, social isolation, depression and a lack of the ability to concentrate. New Hope for Growth Hormone Deficiency: Recombinant human growth hormone has been approved by the Food and Drug Administration for adult men and women in the treatment of hypopituitarism and somatotropin deficiency. If one suffers with hypopituitarism, HGH therapy is available as normally payable under an insurance policy. As part of our
1996 Hypopituitary Registry, patients receive HGH replacement therapy and testing under supervision. Based on the literature and our experience with HGH replacement, the positive changes noted may also apply to individuals with low growth hormone levels. The term used is somatotropin deficiency syndrome. We also treat individuals with IGF-I levels below 200 ng/ml with recombinant HGH in our I.R.B. approved registry. But, such individuals personally pay for HGH.
Note that by combining 'global hormonal' replacement therapy
from our life-pryamid with Calciferol, DHEA, thyroid, testosterone, estrogen, and progesterone when indicated with HGH, the dosage, costs and side-effects are minimized.
Changes with Growth Hormone Replacement
Cardiovascular and Lipid Metabolism
The potential role of HGH in the maintenance of the skeleton is its ability to make and repair these tissues. HGH stimulates osteoblast (bone) and fibroblast (supporting tissue) proliferation. In a recent study using the sensitive techniques of quantitative tomography and single photon absorptiometry, significant increases of 5% and 4% were demonstrated in spinal and cortical bone density over 12 months of therapy in HGH-deficient adults(4). It thus appears that HGH administration may act to improve skeletal repair of not only bone and skin but all organs as well.
Other anabolic effects include a gain of muscle and renewed appetite, better exercise capacity, increased lung capacity, and faster wound healing. Many report there 'old age spots', skin "senile keratosis" disappear within two months of HGH therapy.
Side Effects with Low Dose HGH Replacement
Positive Effects of HGH Replacement Get Lean: Loss of fat and increase in muscle mass combine for up to 20 pound shift in body composition. This equates to a general feeling of physical well being, a stronger libido, and improved self image.
Get Energetic: Without a need for the afternoon food cravings of sweets, caffeine, stimulants or nicotine, HGH patients have more energy. This improves both their self control image and their general health state (because they exercise). Get Smart: An interesting yet unproved side-effect of HGH has been the return of mental acuity and a "sharp" memory. Such HGH improves the vascular and intracellular nutrient support for cells, it is not surprizing that this has been reported by many individuals.
References Salomon F, Cuneo RC, Hesp R, et al. The Effects of Treatment with Recombinant HGH on Body Composition and Metabolism in Adults with Growth Hormone Deficiency. New Eng JMed1989;321:1797-03. Bengtsson BA. The Consequences of Growth Hormone Deficiency in Adults. Acta Endocrin 1993;128:2-5. Cuneo RC, Salomon F, Wiles CM et al. HGH Treatment in GH Deficient Adults. II. Effects on Exercise Performance. J Appl Physiol 1991;70:695-700. O’Halloran DJ, Tsatsoulis A, Whitehouse RW et al. Increased Bone Density after Growth Hormone (HGH) Therapy in Adults with Isolated HGH Deficiency. J Clin Endo Metab 1993;76:1344-48. McGauley GA, Cuneo RC, Salomon F et al. Psychological Well-Being Before and After Growth Hormone Treatment in Adults with HGH Deficiency. Hormone Research 1990;33(Suppl 4):52-54. Bengtsson BA, Eden S, Lonn L et al. Treatment of Adults with Growth Hormone (HGH) Deficiency with Recombinant (HGH).J Clin EndoMetab1993;76:309-17. Johnston DG, Bengtsson BA. The Effects of GH and GH Deficiency on Lipids and the Cardiovascular System.Acta Endocrinologica 1993;128(Suppl 2):69-70. Amato G, Carella C, Fazio S et al. Body Composition, Bone Metabolism, and Heart Structure and Function in Growth Hormone (HGH)-Deficient Adults Before and After HGH Replacement Therapy at Low Doses. J. of Clinical Endocrinology&Metabolism. 1993;77:1671-76. Fazio S, Sabatini D, Capaldo B, et.al. A preliminary study of GH in the treatment of dilated cardiomyopathy. New Engl J Medicine.1996;334:809-14.
It is important to reiterate that
New Hope for Growth Hormone Deficiency:
Positive Effects of HGH Replacement
Bengtsson BA. The Consequences of Growth Hormone Deficiency in Adults. Acta Endocrin 1993;128:2-5.