for Diabetic Men
Understanding Diabetes-Part 1
Edward Lichten, M.D.,PC
189 Townsend Street Second Floor
Birmingham, MI 48009
the Medical Treatment of Diabetic Men!
Prescribe Testosterone for Best Diabetic Control!
Testosterone replacement to
diabetic men reduces the need for insulin, eliminates the need for
expensive oral agents and improves glycemic control by reducing the risk
of hypogylcemic crashes that may be life-threatening.
Dr. Edward Lichten
announces the results of his 10-years of research in the
Medical News November 13, 2006 and has his keynote lecture from
December 2006 to the
American Academy of Anti-Aging Medicine on the internet.
In 1922, Banting and
Best discovered insulin and changed the world of medicine. Not only did
they discover a natural therapy to prevent death from diabetes, they
gave away their patent to humanity. Today, 85 years later, we have
proven that injectable testosterone is, in fact, more important than
insulin because it is applicable to 5 times more diabetic men and
another yet undiagnosed 10 fold.
In 1996, I discovered
that my fasting insulin dropped from 10 miu/ml (borderline) to less than 2 while
on injectable testosterone therapy. An adult diabetic male, J.N., 48
years old with confirmed abnormal glucose tolerance was able to lose 85
pounds in 10 months and regainhis youthful physical, exercise and sexual
vigor while on testosterone replacement. When retested at two
years, his glucose tolerance was entirely normal.
This information and
more gleaned from another 12 diabetic men and women convinced James
Sowers, M.D., professor and chairman of metabolism and endocrinology to
support a pilot study at Providence Hospital in Detroit in 1997. Project
1. All diabetic men
were hypogonadal based on measurement of total testosterone or
2. All men showed
improvement in glycemic control on injectable testosterone therapy.
3. All men reported improvement in sexual function or less depression
and improved sleep on injectables.
4. Two-thirds of the adult onset diabetic men, many who were diabetic
for more than four years, showed a flat insulin response to the oral
glucose given at the glucose tolerance test. These individuals uniformly
stopped their prescription hypoglycemic medications without worsening
their diabetic condition.
testosterone lowered the need for insulin in the insulin dependent
diabetics and improved the glycemic control in adult men after they had
discontinued sulfonylurea medications.
The role of
testosterone in diabetic men is to improve the transport of sugar
(glucose) from the blood stream into the cell. If insulin is one of the
two keys to the safety-box (cell), then
testosterone bound to SHBG is the other. Simply spoken, testosterone
reduces the need for more and more insulin. And when the individual
needs to raise sugar (glucose) from stored
fat, testosterone increases the glycogen-to-glucose conversion making
glucose available averting a potential hypoglycemic crisis.
Therefore, there should
be no fear about beginning testosterone injection replacement in diabetic
men without the risk factors of elevated PSA, prostate or testicular
cancer. Gels do not work! The skin aromatizes testosterone to estradiol
worsening in time the estradiol/testosterone ratio and accelerating the
progress to insulin resistance. Routine replacement for any man is 100mg
IM weekly; Kapoor used 200mg IM every two weeks. We routinely use 150 mg
weekly for men over 200 pounds and follow the testosterone, SHBG and
estradiol every 6 weeks. Testosterone may raise hemoglobin so a donation
of one unit to the Red Cross may be suggested every 3-4 months.
Otherwise,few side-effects except increased libido, increased muscle mass,
weight loss and drops in total cholesterol are usually reported.
1. JAMA CONFIRMS ALL DIABETIC MEN are HYPOGONADAL
JAMA 2006;295:1288-1299. EL Ding. Harvard.
Boston USA. Cross-
sectional studies indicated that testosterone level was significantly
men with type 2 diabetes ....Similarly, prospective studies showed that
with higher testosterone levels (range, 449.6-605.2 ng/dL) had a 42%
risk of type 2 diabetes
2. EUROPEANS TREATS DIABETIC MEN WITH TESTOSTERONE
Kapoor D. Eur J Endocrinol 2006; 254(6):
replacement therapy improves insulin resistance, glycaemic control,
adiposity and hypercholesterolaemia in hypogonadal men with type 2
US RESEARCHERS show NANDRALONE, a 19-nortesteosterone, ENHANCES GLUCOSE
UPTAKE in NORMAL MEN.
C, Jobbs, R.Jones and S. Plymate in JCEM
conclude that the treatment of normal men with supra-physiological doses
of either Testosterone enanthate or Nandralone-decanoate, does not
adversely affect glucose metabolism. treatment with a non-aromatizable
androgen, such as ND, actually improves glucose metabolism by enhancing
non-insulin-mediated glucose disposal.