Heart Disease

Another Testosterone Deficient State!

Edward Lichten, M.D., PC
555 South Old Woodward Suite #700
Birmingham, MI 48009 


Two More Articles Confirm Testosterone Relieves Angina in Men!

Testosterone Patches Improve Exercise Capacity in Men with Angina
Reuters Medical News____ TORONTO, June 22, 2000

Improving the quality of life and exercise performance in men with stable angina might be as simple as getting them to wear testosterone patches, Dr. Katherine M. English said here at the annual meeting of the Endocrine Society.

Dr. English, a research fellow at the Royal Hallamshire Hospital in Sheffield, England, pointed out that there have been fears that increased testosterone levels increase the risk of heart disease and prostate cancer. But studies in recent years have indicated that not only are low testosterone levels common in men with angina, but, low levels may actually be a risk factor.

Testosterone levels drop as a part of the male aging process, and it may be that levels that drop below a certain point are too low, she said. In addition, studies of castrated animals show that the lowered resulting androgen levels are associated with greater atheroma formation.

To investigate, Dr. English and colleagues randomized 46 men with chronic stable angina to wear either active testosterone patches, each of which contained 2.5mg of testosterone, or placebo patches. The men wore two patches each day for 12 weeks.

They underwent exercise testing at baseline, then again at 4 and 12 weeks into the study. They were also asked to fill out quality-of-life questionnaires. The researchers found that there was a significantly greater improvement in exercise tolerance among the men who wore the active patches, compared with those who had used placebo. They also reported superior quality-of-life scores.

The improvement seen in men wearing active patches may be caused by a vasodilatory effect of the male hormone, "Which may improve the blood supply to the myocardium, thereby reducing symptoms of angina," Dr. English said.

Alternative Medicine Digest July, 2000 page 18

Hormones in Men's Heart Health

Half a million men in the United States die from diseases of the heart and blood vessels each year. Now some doctors are suggesting that increased cardiovascular risk may be linked to andropause (the male equivalent of menopause), when a reduction of male hormones (androgens) begins to affect the body in several significant ways.

While most conventional physicians ignore the role of testosterone and other hormones in men's cardiovascular health, it is becoming clear that testosterone plays an important role in preventing the blockages that can lead to heart attacks, stroke, difficulty walking, or gangrene. Testosterone levels decline with age and restoring them can help protect against arthero-sclerotic disease in men. since blood carries oxygen and nutrients, restricted blood flow greatly impacts those organs in need of the life-giving supplies.

Until recently, many believed that elevated testosterone levels were dangerous for the heart. This holds true for women, not men. Both low testosterone levels and high estradiol levels (the most common estrogen ) have been linked with cardiovascular disease in men. It may not be just the testosterone levels that is significant, but the ratio of estrogen to testosterone that is critical. Elevation of the estrogen-testosterone ratio also was linked with mild diabetes. The ratios are opposite for women. Estrogen has a heart protective function for them.

Numerous studies have shown that testosterone helps prevent heart attacks because it reduces cholesterol, triglycerides, and blood glucose levels. The hormone also normalizes blood clotting.

There are a number of natural ways to normalize testosterone levels. Find out more by reading Maximizing Your Vitality & Potency: For Men Over 40 by Jonathan V. Wright, M.D., and Lane Lenard, Ph.D., published by Smart Publications, PO Box 4667, Petaluma, CA 94955; $14.95; fax (707)763-3944.

From Well-Being Journal


Lichten's Pearls

1. Measure a man's laboratory tests to determine his standard risk factors.

2. Bio-available testosterone is measured as the Free Androgen Index (FAI). Raw FAI is calculated as [total testosterone]/ [sex hormone binding globulin]. Calculate final FAI by multiplying the raw FAI by 0.3 conversion factor.

3. Normal range greater than 0.7. Most men are at 0.3.

4. Replace testosterone with pellets or injections as the topical preparations raise the estrogens and SHBG.

5. High SHBG correlates directly to insulin resistance and pre-diabetes. Suppress SHBG with Deca-Durabolin 100mg intramuscularly weekly.

6. The goal is to reach a testosterone level between 450-800 ng/dl; an estradiol less than  25mg/dl and a SHBG at 15-20 nmol/L.